WHATEVER YOUR RESEARCH AIM IS, YOU NEED A CULTURE SUBSTRATE THAT GUARANTEES THE HIGHEST CELL QUALITY AND YIELD.

We offer an expansive portfolio of human recombinant laminin cell culture substrates for a variety of applications, including reliable expansion of pluripotent cell and differentiation and maintenance of specialized cell types.

All our matrices are chemically defined and animal component-free and allow you to imitate the natural cell-matrix interactions in vitro. 

The authentic cell culture environment provides more consistent and reliable cellular responses and improves cell functionality. 

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Click on the icons below to read more about how Biolaminin substrates can be used for specific cell applications        

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While many protocols successfully recapitulate the temporal developmental processes via well designed medium formulations, the majority of protocols ignore the role of basement membrane proteins. Adhesion is not only about making cells stick, but also about the interaction between the culture substrate and cells which can influence cell behavior. The type of cell culture substrate used will have a great impact on your research and will save you both time and cost. 

Laminins are large multidomain, glycoproteins of the extracellular matrix. They are a major component of the basal lamina of the basement membrane, a protein network foundation for most cells and organs. The laminins are an important and biologically active part of the basal lamina, influencing cell differentiation, migration, and adhesion. Laminins are heterotrimeric proteins that contain an α-chain, a β-chain, and a γ-chain, found in five, four, and three genetic variants, respectively. There are to date at least 16 distinct isoforms identified in mammals, named based on their chain composition. The assembled laminin molecule forms a cross-like structure that can bind to other extracellular matrix molecules and to cellular receptors, which helps anchor organized tissue cells to the membrane.

BioLamina's Biolaminin substrates are the only original full length, recombinant laminins on the market. There are many binding sites on the full-length laminin molecule which can interact with cell membrane receptors, triggering vital intracellular signaling pathways and regulate cellular responses, such as cell anchorage, survival, proliferation, migration, organization and specialization.

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