Biologically relevant
A biologically relevant matrix that mimics the authentic ECM-cell interaction for improved cell performance.
Defined and animal-free
The products are defined and animal origin-free. All materials used in the production of Biolaminin 521 CTG have full traceability.
Minimized variation
No lot-to-lot variation and uniformed pluripotency gene expression patterns between different cell lines give more standardized experiments.
Effective specialization
More efficient differentiation, enhanced cell maturation, polarization, and organization of specialized cell types, such as hepatocytes, cardiomyocytes, and neurons.
High quality and yield
Fast proliferation rate with maintained genetic integrity and stemness, facilitates the use of low passage cell lines for the production of clinically relevant cell numbers of differentiated cell types.
Full documentation
Full traceability documentation, such as Certificate of Origin and Certificate of Analysis is available for the cell therapy grade Biolaminin 521.
Click on the icons below to read more about how Biolaminin substrates can be used for specific cell applications
|
|
hPSC DERIVATION AND EXPANSION |
|
|
|
|
|
NEURONS, GLIA & NEURAL STEM CELLS |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
SPLEEN CELLS |
|
|
|
|
|
|
|
|
ADIPOSE CELLS |
|
|
|
|
|
GERM CELLS |
|
|
|
|
|
|
|
|
Laminins are large multidomain, glycoproteins of the extracellular matrix. They are a major component of the basal lamina of the basement membrane, a protein network foundation for most cells and organs. The laminins are an important and biologically active part of the basal lamina, influencing cell differentiation, migration, and adhesion. Laminins are heterotrimeric proteins that contain an α-chain, a β-chain, and a γ-chain, found in five, four, and three genetic variants, respectively. There are to date at least 16 distinct isoforms identified in mammals, named based on their chain composition. The assembled laminin molecule forms a cross-like structure that can bind to other extracellular matrix molecules and to cellular receptors, which helps anchor organized tissue cells to the membrane.
BioLamina's Biolaminin substrates are the only original full length, recombinant laminins on the market. There are many binding sites on the full-length laminin molecule which can interact with cell membrane receptors, triggering vital intracellular signaling pathways and regulate cellular responses, such as cell anchorage, survival, proliferation, migration, organization and specialization.
READ MORE
"WOW!
I wasted so much time on other stuff."
"We have struggled to establish a GMP manufacturing process for a DA neuron therapy for Parkinson's Disease. The recombinant laminins from Biolamina really made a world of difference! We have greater efficiency than ever before and we now have a high yield, high-quality GMP differentiation protocol ready to use."
Stem cell culture
Pluripotent stem cell culture is easy on human recombinant Biolaminin 521 substrates. The Biolaminin 521 LN (LN521) stem cell matrix is a feeder-free, chemically defined and animal origin-free cell culture system that supports high cell survival and fast proliferation of hESC and iPSC.
The LN521 matrix is biologically relevant and allows low-density seeding of single cells without the need of ROCKi. The cells grow as a homogenous monolayer and remain pluripotent without spontaneous differentiation.
- x
Expansion of human PSC
Mesenchymal stem cells
Clonal cell culture applications
Eye cells
Cardiac cells
Neural cells
Skeletal muscle cells
Kidney cells
Hepatic cells
Cancer cells
Lung cells
Animal stem cells
Endothelial cells
Pancreatic cells
Intestinal cells
Normal and cancerous mammary cells
Epithelial cells
Biolaminin 521 CTG
Biolaminin 521 CTG cell therapy grade cell culture matrix makes pluripotent stem cell culture easy. A defined, animal origin-free and biologically relevant cell culture system for better cell models.
- x
Expansion of human PSC
Clonal cell culture applications
Eye cells
Cardiac cells
Neural cells
Skeletal muscle cells
Kidney cells
Hepatic cells
Cancer cells
Lung cells
Animal stem cells
Mesenchymal stem cells
-
Endothelial cells
-
Pancreatic cells
-
Intestinal cells
-
Normal and cancerous mammary cells
-
Epithelial cells
Biolaminin 521 MX
Biolaminin 521 MX research-grade cell culture matrix makes pluripotent stem cell culture easy. A defined, animal origin-free and biologically relevant cell culture system for better cell models.
- x
Expansion of human PSC
Mesenchymal stem cells
Clonal cell culture applications
Eye cells
Cardiac cells
Neural cells
Skeletal muscle cells
Kidney cells
Hepatic cells
Cancer cells
Lung cells
Animal stem cells
-
Endothelial cells
-
Pancreatic cells
-
Intestinal cells
-
Normal and cancerous mammary cells
-
Epithelial cells
Biolaminin 521 LN
Biolaminin 521 LN research-grade cell culture matrix makes pluripotent stem cell culture easy. A defined, animal origin-free and biologically relevant cell culture system for better cell models.
